Print a clean webpage with Safari’s Reader view
Some sites such as The New York Times offer a “Print” layout that removes most of the ads for printing. If the particular site does not offer that, the new Reader view in Safari 5 can serve as a replacement. Just press Command+P while in Reader mode, and the printed version will use that clean layout.

AppZapper - zapping Dashboard widgets

AppZapper - zapping plugins

AppZapper - zapping Sys Pref panes
AppZapper, an uninstaller utility from Austin Sarner and Brian Ball, is not restricted to apps. It can sniff out the Dashboard widgets, web and app plugins, and System Preferences panes that you’ve installed, as well as the support files they spread across your Mac’s file system. You can trash just the main app, plugin, or widget, the support files, or the whole shebang with a click.
Quickly use Exposé on a single app
When you click and hold on a Dock icon in 10.6 Snow Leopard, other apps hide temporarily and that app goes into Exposé, showing you just its windows. You can also use the Exposé key on your keyboard, then press Tab to cycle through apps like this one-by-one, or click on an app in the Dock while in Exposé.
iChat Video Conference gestures
When in a video chat you can use the zoom in gesture (pinch-outwards) on a MacBook’s trackpad, a Magic Mouse, or Magic Trackpad to make the video fullscreen, and zoom out gesture (pinch-inwards) to return the video chat to window mode.
Show hidden files in Snow Leopard’s Open/Save dialogs
In 10.6 Snow Leopard you can temporarily show hidden files within open/save dialog boxes by hitting “Command + Shift + .”
Delete unused iOS device backups to reclaim space - Apple support document
via Shawn Blanc, who deleted a few and recovered over 3GB of space. iTunes creates a new, separate backup every time you restore your device from scratch (i.e., you choose not to “restore from backup”).
Undo a closed tab in Safari 5
I love that I can now easily reopen the most recent tab I’ve closed in Safari 5 using Cmd+Z, the system-wide command for for “undo.” Such a life saver.
When you option-click the Sound menu item in Snow Leopard, you can select the sound input and output devices.
Copy a screenshot to the clipboard instead of the desktop
Many people are familiar with the Command+Shift+4 keyboard shortcut to access Mac OS X’s screenshot tool. This command lets you drag around an area of the screen to capture it as a PNG file on your desktop (use Command+Shift+3 to snap your entire display at once). If you press Space after invoking this command, you can capture any open window that you mouse over and click on.
If you add Control to this command (Command+Control+Shift+4), Mac OS X will capture your screenshot to the clipboard instead of creating a file on your desktop. This is ideal for pasting into image editors like Acorn and Pixelmator, and cutting down on desktop clutter.
In fact, the image editors are smart, and they’ll check your Mac’s clipboard for an image when creating a new file. If they see one, the new file dialog dimensions will default to those of the image on your clipboard.

Keyboard Viewer, accessible from the Keyboard & Character Viewer menu bar utility, won’t visualise the letters you type when using your Mac’s physical keyboard to enter a password.