Tweetie for Mac has some great keyboard shortcuts
22. Oct, 2009 
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Tweetie for Mac lets you switch between the Timeline, Replies, Direct Messages, and Search panels of your account with Command-1, -2, -3, and -4, relatively speaking.
If you use more than one Twitter account in Tweetie, you can switch between them by using Command-Shift-Up/Down arrows. This means you can switch between any account, and any panel [...]
